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The Effect of Ascorbate on the Maintenance of 2,3‐Diphosphoglycerate (2,3‐DPG) in Stored Red Cells
Author(s) -
Wood L. A.,
Beutler E.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01774.x
Subject(s) - diphosphoglycerate , preservative , chemistry , red cell , sodium citrate , blood preservation , sodium ascorbate , food science , biochemistry , ascorbic acid , andrology , medicine , hemoglobin , pathology
S ummary . The addition of adenine and ascorbate to citrate‐phosphate‐dextrose solution has been shown to prolong the maintenance of 2,3‐DPG levels of stored blood. The final concentrations of adenine and sodium ascorbate in the blood‐preservative mixture were 0.5 and 5.05 m m , respectively. In most cases, red cells stored in this preservative maintained levels of 2,3‐DPG greater than 50% of fresh values for 28 days. Red‐cell viability was not adversely affected by ascorbate. The mechanism by which ascorbate produced this effect is unknown.