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Linolenoyl Sorbitol and the Fragility of Hereditary Spherocytes
Author(s) -
Livne Avinoam,
Aloni B.,
Moses S.,
Kuiper P. J. C.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01755.x
Subject(s) - erythrocyte fragility , hereditary spherocytosis , sorbitol , fragility , spherocytosis , hemolysis , medicine , chemistry , biochemistry , splenectomy , spleen
S ummary . Linolenoyl sorbitol decreased uniformly the osmotic fragility of normal human red cells. When added to red cells of patients with hereditary spherocytosis (HS), the synthetic lipid afforded the most fragile cells the greatest shift in osmotic stability. The greater the osmotic fragility of red cells from different patients, the greater the protective effect afforded by the added lipid. Linolenoyl sorbitol fully reversed the increased fragility of vinblastin‐treated red cells. The results indicate a causal relationship between the lipid composition and the increased fragility of red cells in hereditary spherocytosis.