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A Second Type of Hereditary Persistence of Foetal Haemoglobin in India
Author(s) -
Schroeder W. A.,
Huisman T. H. J.,
Sukumaran P. K.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01722.x
Subject(s) - heterozygote advantage , genetics , persistence (discontinuity) , glycine , biology , gene , genotype , amino acid , geotechnical engineering , engineering
S ummary . Six individuals in four Indian families have 25–30% foetal haemoglobin in which the two types of γ chains (the G γ chain with glycine in position 136 and the A γ chain with alanine in that position) are present in a ratio of 70:30. It is suggested that these heterozygotes form a distinct subgroup of the Hb G γ Hb A γ class of the hereditary persistence of foetal haemoglobin. In three relatives this HPFH condition occurs together with β‐thalassaemia. It is concluded that the β‐thalassaemia is of the type in which the ratio of G γ: A γ chains is 3:1 as in the newborn.