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An Analogue Model of Granulopoiesis for the Analysis of Isotopic and Other Data Obtained in the Non‐steady State
Author(s) -
Reeve J.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01712.x
Subject(s) - granulopoiesis , labelling , chemistry , biology , biochemistry , microbiology and biotechnology , haematopoiesis , stem cell
S ummary . An analogue model of human granulopoiesis incorporating feedback control is presented which is less restricted than previous models. The model simulates kinetic data from human DF 32 P and 3 H‐thymidine labelling experiments, and the data obtained by Morley & Stohlman in mice (1970) following destruction of four‐fifths of the marrow. Support for King‐Smith & Morley's (1970) suggestion that cyclic neutropenia may be a stem cell defect is forthcoming, but only after the addition of a further negative feedback loop simulating a granulocyte‘chalone’ or a considerable reduction in the time required for precursor cell division. The value of the model in the interpretation and design of kinetic studies, particularly in the non‐steady state, is discussed.