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Bone‐Marrow Toxicity of Methotrexate: A Reassessment
Author(s) -
Douglas I. D. C.,
Price L. A.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01688.x
Subject(s) - methotrexate , toxicity , bone marrow , medicine , pharmacology
S ummary . The effects of methotrexate on the haemopoietic system are considered in the light of an experimental kinetic model. This model explains why toxicity occurs and suggests how it may be avoided.