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Surface Immunoglobulins on Lymphocytes in Chronic Lymphocytic Leukaemia and Lymphosarcoma
Author(s) -
Wilson J. D.,
Hurdle A. D. F.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01682.x
Subject(s) - surface immunoglobulin , antibody , peripheral blood , chronic lymphocytic leukemia , immunology , lymphocyte , medicine , population , pathology , b cell , leukemia , environmental health
S ummary . The density of surface immunoglobulins on peripheral blood lymphocytes from 10 patients with chronic lymphocytic leukaemia (CLL) and three patients with lymphosarcoma was examined using a sandwich radio‐immunolabelling technique. In healthy people two populations of lymphocytes are seen: densely labelled cells with a high surface immunoglobulin density or B cells and lightly labelled T cells. CLL lymphocytes were found to comprise a single population with labelling characteristics of B lymphocytes in eight patients and of T lymphocytes in two patients. In the three lymphosarcoma patients grain count histograms revealed two or three populations where the abnormal lymphocytes fell into the T cell type in two and into the B cell group in one patient. There were no essential clinical differences between these three patients.