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Effect of Warfarin Anticoagulation on Vitamin‐K 1 Metabolism in Man
Author(s) -
Shearer M.J.,
Burney A.,
Barkhan P.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01673.x
Subject(s) - warfarin , vitamin , metabolite , vitamin k , chemistry , pharmacology , excretion , medicine , endocrinology , atrial fibrillation
S ummary . Three normal men were injected intravenously with 1 mg [1′,2′‐ 3 H 2 ]‐vitamin K 1 before and after treatment with therapeutic doses of warfarin for 8–10 days. Warfarin treatment caused a delayed clearance of lipid‐soluble radioactivity from the plasma. This was found to be due to the accumulation in the plasma of a metabolite with the properties of vitamin K 1 oxide as shown by thin‐layer chromatography: the rate of clearance of vitamin K 1 from the plasma was not affected. Under warfarin treatment there was about a two‐fold increase in the urinary excretion of radioactivity.