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Effect of Alpha‐ and Beta‐blocking Drugs on the Clotting and Fibrinolytic Response to Venous Stasis in Man
Author(s) -
Ponari O.,
Civardi E.,
Megha A.,
Pini M.,
Potì R.,
Dettori A. G.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01672.x
Subject(s) - fibrinolysis , phentolamine , venous stasis , propranolol , partial thromboplastin time , medicine , coagulation , adrenergic receptor , endocrinology , alpha (finance) , thromboplastin , pharmacology , receptor , surgery , construct validity , patient satisfaction
S ummary . The changes in coagulability and in fibrinolytic activity induced in local blood by venous stasis in man are not prevented by blocking of alpha‐ and beta‐adrenergic receptors. Administration of l‐propranolol and of l‐propranolol plus phentolamine in adequate doses just before the execution of a tourniquet test failed to inhibit the major changes, i.e. rise in factor‐VIII level, shortening of partial thromboplastin time (PTT) and euglobulin lysis time (ELT), hypercoagulable pattern on thromboelastogram, following venous stasis. Some other clotting tests remained unchanged in all experimental conditions. Physiopathological implications of these results are discussed, taking into account the possible role of the adrenergic system in the control of a postulated equilibrium between blood coagulation and fibrinolysis.