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Increased Platelet Adhesiveness as a Familial Characteristic
Author(s) -
Papayannis A. G.,
Geary C. G.,
Burn Aileen,
Israëls M. C. G.
Publication year - 1973
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1973.tb01669.x
Subject(s) - abnormality , medicine , von willebrand factor , platelet , psychology , gastroenterology , psychiatry
S ummary . Two families are described in which many members were shown to have increased platclet adhesiveness, using a modification of the Salzman techniquc. The abnormality appears to be inherited as an autosomal dominant characteristic. In addition, one member of each family had an abnormally low level of plasma factor VIII (AHG) and a moderatcly severe haemorrhagic disorder, while two members of one of the families had factor‐VIII levels at the lower limit of normal. Several individuals showed a mild haemorrhagic disorder, but none had thrombotic manifestations. The significance of these findings and their distinction from those present in von Willebrand's disease is discussed.