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Inhibition of Methaemoglobin Reduction by Sodium Salicylate
Author(s) -
Worathumrong Nimnuan,
Grimes A. J.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb08879.x
Subject(s) - sodium salicylate , methemoglobin , chemistry , sodium nitrite , sodium , biochemistry , pharmacology , hemoglobin , medicine , food science , organic chemistry
Summary. Normal, human red cells containing nitrite‐induced methaemoglobin were incubated in glucose‐supplemented serum in the presence or absence of sodium salicylate. It was shown that sodium salicylate inhibits methaemoglobin reduction. Studies performed on haemolysates demonstrated that this effect on red cells was due to the inhibition by sodium salicylate of diaphorase. This inhibitory action of sodium salicylate was due primarily to salicylate ions and, secondarily, to the accompanying sodium ions.