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Small Intestinal Mucosal Abnormalities and Disaccharidase Activity in Pernicious Anaemia
Author(s) -
Peña A. S.,
Callender Sheila T.,
Truelove S. C.,
Whitehead R.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb08878.x
Subject(s) - disaccharidase , medicine , pernicious anaemia , biopsy , gastroenterology , intestinal mucosa , pathology , small intestine
Summary. Patients with untreated pernicious anaemia usually show the following morphological and biochemical abnormalities in small‐intestinal biopsy specimens: (1) shortening of villi with diminished surface area; (2) megalocytic changes of the epithelial cells; (3) increased inflammatory infiltrate; (4) generalized depression of disaccharidases. These abnormalities revert to normal following treatment with injections of vitamin B 12 .