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Vitamin B 12 ‐Binding Protein Abnormality in Subjects without Myeloproliferative Disease: I. ELEVATED SERUM VITAMIN B 12 ‐BINDING CAPACITY LEVELS IN PATIENTS WITH LEUCOCYTOSIS
Author(s) -
Carmel Ralph
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb08785.x
Subject(s) - leukocytosis , vitamin , medicine , globulin , vitamin b , endocrinology , abnormality , granulocyte , immunology , gastroenterology , psychiatry
Summary. In a group of 41 patients with leucocytosis of varying degrees and diverse aetiologies, 88% had elevated serum unsaturated vitamin B 12 ‐binding capacity (UBBC). All but three had normal serum vitamin B 12 levels. The UBBC abnormality occurred even with apparently mild leucocytosis. When leucocytosis subsided, spontaneously or due to therapy, UBBC invariably fell, whereas it remained high if granulocyte counts did not fall. Serum vitamin B 12 levels usually showed no change. Factors other than leucocytosis could not be related to the UBBC elevation. However, high UBBC was also found in 15 of 248 subjects with normal granulocyte counts. Seven of these were in states of granulocyte flux. In the eight remaining subjects (3% of the sample), leucocytosis apparently did not exist. Although by the screening method used here the main UBBC elevation appeared to be of beta‐globulin binder, a subsequent report shows a third protein to be responsible (being apparently elevated even in a subject with leucocytosis whose UBBC level was normal). Alpha‐globulin binding was only slightly elevated in most cases.