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Osmotic Resistance of Abnormal Red Cells Exposed to Lead in Vitro
Author(s) -
Qazi Qutub H.,
Go Suat Cheng,
Smithwick Elizabeth M.,
Madahar D. P.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb07098.x
Subject(s) - erythrocyte fragility , hereditary spherocytosis , lead acetate , red cell , in vitro , spherocytosis , chemistry , andrology , hemolysis , immunology , biology , biochemistry , medicine , toxicity , spleen , splenectomy
S ummary . Exposure of normal red cells to lead in vitro is known to result in decreased osmotic fragility. Red cells from a normal individual and from two children with genetically determined red‐cell abnormalities (spherocytosis and elliptospherocytosis) were exposed to lead acetate solution. Osmotic fragility curves were determined for treated and untreated red cells. Exposure to lead was found to increase the osmotic resistance of normal as well as abnormal red cells.