Premium
Iron Transport by Rat Small Intestine in Vitro: Effect of Body Iron Status
Author(s) -
Howard J.,
Jacobs A.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb07094.x
Subject(s) - small intestine , ileum , in vitro , chemistry , duodenum , medicine , endocrinology , biophysics , biochemistry , biology
S ummary . Both mucosal uptake and serosal transfer of iron by everted sacs of rat small intestine were maximal in the duodenum and decreased progressively towards the ileum. Transport of iron against a concentration gradient did not occur in any part of the intestine. When the iron concentration in the bathing medium was varied over the range 10–500 μM a saturable transport process was revealed in the proximal small intestine. In iron‐deficient rats mucosal uptake of iron was increased but in iron‐loaded rats it remained normal. The results suggest that iron transport across the proximal small intestine of the rat in vitro involves a carrier mechanism which responds adaptively to iron deficiency but not to overload.