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Platelet Coagulant Activities in Thrombasthenia
Author(s) -
Walsh P. N.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb07091.x
Subject(s) - platelet , thrombasthenia , clotting time , medicine , hemostasis , clotting factor , coagulation , chemistry , platelet aggregation
S ummary . Methods for assaying four platelet coagulant activities are presented. The results of performing these assays in six patients with thrombasthenia revealed decreased contact‐forming activity (CPFA) and an absence of platelet response to adenosine diphosphate in the CPFA assay. All patients had normal or raised intrinsic factor‐Xa forming activity (XaFA) and decreased platelet factor‐3 activity (PF 3 A), the level of which related poorly to bleeding history. The four patients most severely affected clinically lacked collagen‐induced coagulant activity (CICA), whereas CICA was present in the other two. The important determinants of bleeding severity in thrombasthenia may be the platelet coagulant activities concerned with the initiation of intrinsic clotting (i.e. CICA and CPFA) and not those concerned with the subsequent interaction of clotting factors other than the contact factors (i.e. XaFA and PF 3 A). It is concluded that each of the four coagulant activities studied is separate and distinct from the others, and each has its own biochemical determinants.