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The Metabolism of Maturing Reticulocytes
Author(s) -
Gasko O.,
Da D.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb07089.x
Subject(s) - citric acid cycle , metabolism , mitochondrion , pyruvic acid , biochemistry , energy metabolism , biology , chemistry , endocrinology
S ummary The aerobic metabolism of populations of rabbit reticulocytes separated into age groups by differential flotation was measured by manometric techniques. The activity of the Krebs tricarboxylic acid cycle was studied by following the metabolism of substrates such as [2‐ 14 C]acetate, [3‐ 14 C]pyruvate and [6‐ 14 C]glucose. These mitochondrial activities were found to decline with maturation of the reticulocytes. The mode of decline was studied and its significance is discussed.