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Observations on the Survival of Circulating Reticulocytes
Author(s) -
Zervas J. D.,
Delamore I. W.,
Cunliffe D. J.,
Israëls M. C. G.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb07079.x
Subject(s) - cytotoxic t cell , antibody , antigen , immunology , chemistry , biology , microbiology and biotechnology , medicine , biochemistry , in vitro
S ummary . The survival of reticulocytes carrying HL‐A antigens is reduced in patients with circulating cytotoxic HL‐A antibodies. The survival of mature red cells is also reduced in these patients but to a lesser degree. Both mature red cells and reticulocytes survive longer in patients without circulating cytotoxic antibodies than reticulocytes (but not mature red cells) in a cytotoxic environment. The significance of these findings is discussed.