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Autoantibodies of U Blood Group Specificity in Autoimmune Haemolytic Anaemia
Author(s) -
Marsh W. L.,
Reid Mawon E.,
Scott E. Patricia
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb05709.x
Subject(s) - autoantibody , antibody , antigen , immunology , rh blood group system , medicine , biology
S ummary Autoantibody specificity in acquired haemolytic anaemia of the warm antibody type has been thought to be directed against Rh antigens or the precursors from which they arise. In many cases Rh null red cells fail to react with these antibodies, providing apparent support for the assumption that they have Rh specificity. Rh null red cells are also non‐reactive with anti‐U sera, and in addition have abnormal S and s antigens. We have studied 50 cases of warm antibody autoimmune haemolytic anaemia looking particularly for possible U, S or s blood group specificity of the causative antibodies. In the majority of cases the antibodies were found to be directed against antigens of the Rh complex, but in three cases multi‐specific autoantibodies were shown to have complex specificity involving the Rh and U blood groups.