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Experimental Enterogenous Cyanosis and Anaemia
Author(s) -
Westphal Robert G.,
Azen Edwin A.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb05707.x
Subject(s) - neomycin , phenacetin , urine , incubation , hemolysis , oxidative damage , pharmacology , pigment , andrology , chemistry , biology , microbiology and biotechnology , physiology , biochemistry , medicine , oxidative stress , antibiotics , immunology , organic chemistry
S ummary Rats with jejunal pouches develop an anaemia which js partially haemo‐lytic in nature and accompanied by small amounts of methaemoglobm (MHb) and sulphaemoglobin (SHb). These pigments increase upon sterile incubation of the blood. The presence of these abnormal pigments indicates that oxidativc damage has occurred. Most of the abnormalities improve on feeding neomycin. Rats with blind pouches are more sensitive than normal rats to the oxidant effects of phenacetin on RBCs. RBCs incubated in urine from rats with pouches developed more MHb than RBCs incubated in urine from normal rats. We conclude that bacterial overgrowth in the intestine, by means yet undetermined, can cause oxidative damage to RBCs and that this effect can be produced by constituents of the urine of rats with pouches. This toxic effect of bacterial overgrowth may condition RBCs to oxidant: drug damage.