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Bone Marrow Involvement in Burkitt's Lymphoma: Results of a Prospective Study
Author(s) -
Bluming Avrum Z.,
Ziegler John L.,
Carbone Paul P.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb05684.x
Subject(s) - medicine , bone marrow , complication , lymphoma , pathology , surgery , gastroenterology
S ummary Eighty‐five previously untreated patients with Burkitt's lymphoma were studied prospectively for the development of generalized bone marrow involvement by tumour. Fourteen (16%) of the patients in this series manifested marrow tumour involvement at some time during the course of their disease and seven of these presented with this complication. Only 20% of the affected patients had a peripheral leukaemic picture with a high percentage of circulating tumour cells. The prognosis associated with this complication appeared to be slightly worse in patients developing this picture following initial therapy than in those presenting with it. Pretreatment bone marrow lymphocyte counts were found to be 50% higher in patients who later developed bone marrow tumour involvement than in those who remained free of this complication. The implications of these observations are discussed.