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Observations on the Mechanism of the Haematological Changes in the Haemolytic Uraemic Syndrome of Infancy
Author(s) -
Metz J.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb03504.x
Subject(s) - haemolysis , haemolytic uraemic syndrome , platelet , medicine , coagulation , fibrinogen , immunology , gastroenterology , chemistry , biochemistry , escherichia coli , gene
S ummary . The haemolytic uraemic syndrome of infancy (HUSI) is one of a group of diseases described by Brain, Dacie and Hourihane under the generic name ‘microangiopathic haemolytic anaemia’ (MHA). Survival studies using labelled red cells support the concept that increased haemolysis results from damage to the red cells sustained in small blood vessels. Studies with labelled platelets and fibrinogen fail to provide evidence for continuing intrarenal coagulation once the classic triad of haemolytic anaemia, thrombocytopenia and renal failure has been established.