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A Comparison of Erythrocyte Characteristics in Sickle Cell Syndromes in Jamaica
Author(s) -
Serjeant G. R.,
Serjeant B. E.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb03473.x
Subject(s) - red cell , cell , disease , hemoglobinopathy , medicine , red blood cell , sickle cell anemia , immunology , gastroenterology , biology , genetics
S ummary . Red‐cell characteristics were studied in the steady state in three sickle‐cell syndromes, homozygous sickle‐cell disease (SS), sickle‐cell/haemoglobin‐C disease (SC), and sickle‐cell/β‐thalassaemia (S/thal). Hb‐SC disease had the highest haemoglobin levels, red cell counts, and mean corpuscular haemoglobin concentrations, all of which may contribute to the high thrombotic tendency noted in this disease. The two types of S/thal (with and without Hb A) generally had different haematological features. The non‐Hb‐A type of S/thal, which may resemble SS disease on electrophoretic techniques and present a diagnostic problem, was distinguishable on many red cell characteristics reported here.