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The Mode of Action of Antibodies which Destroy Factor VIII
Author(s) -
Biggs Rosemary,
Austen D. E. G.,
Denson K. W. E.,
Rizza C. R.,
Borrett R.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb03467.x
Subject(s) - antibody , chemistry , mathematics , immunology , medicine
S ummary . In 1959 Biggs & Bidwell proposed the hypothesis that the reaction between antibody and factor VIII could be interpreted as a second‐order reaction and that in antibody excess the amount of antibody present could be measured using a linear calibration graph relating the logarithm of residual factor VIII to antibody concentration after incubation for a fixed period of time. This hypothesis has been re‐examined because antibody is seldom present in excess in most routine test systems and in view of a new and attractive hypothesis put forward by Pool & Miller (1972). All the evidence seems to suggest that the original hypothesis of Biggs & Bidwell is adequate for assessing the potency of antibodies of the type occurring in many haemophilic patients.