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Glycolytic and Respiratory Enzyme Activity in Relation to Leucocyte Maturation
Author(s) -
Stuart J.,
Simpson Jennifer S.,
Wallin Josephine M.
Publication year - 1972
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1972.tb03461.x
Subject(s) - glycolysis , lymphoblast , enzyme , biology , lymphoma , mitochondrion , succinate dehydrogenase , biochemistry , cell culture , microbiology and biotechnology , immunology , genetics
S ummary . Low activity of intramitochondrial dehydrogenases and of a mitochondrial membrane hydrogen shuttle system has been demonstrated cytochemically in the lymphoblast and in three Burkitt lymphoma cell lines; this contrasts with a relatively high activity of extramitochondrial glycolytic enzymes and may render these cells abnormally sensitive to glycolytic enzyme inhibition. This pattern of enzyme activity was not seen in normal and leukaemic myeloid cells at any stage of maturation, nor in lymphoid cells undergoing benign hyperplasia, and appears to be related to mitochondrial number. This explanation is in contrast to previous claims of specific enzyme deletions in solid tumours and in mouse lymphoma.