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Deduction of Mean Red‐Cell Life‐Span from 51 Cr Survival Curves *
Author(s) -
Garby L.,
Mollison P. L.
Publication year - 1971
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1971.tb07068.x
Subject(s) - life span , red cell , nuclear medicine , mathematics , medicine , gerontology
S ummary . Twenty‐two estimates of Cr red‐cell survival in normal subjects, using the ‘citrate‐wash’ method of labelling, are described; results obtained with this method are shown to have given closely similar results in three different laboratories. By contrast, methods in which 51 Cr is added to ACD blood have given a much wider range of normal values. In 14 patients red‐cell survival was estimated simultaneously with DF 32 P and 51 Cr, the latter results being corrected for Cr elution using empirical factors. Estimates of mean red‐cell life‐span by the two methods agreed fairly closely. It is concluded that when 51 Cr is used as a red‐cell label, the citrate‐wash method, or some other method which has also been shown to give reproducible results in different laboratories, should be used and the results should then be corrected so as to obtain an estimate of mean life‐span. Such estimates should be more useful in clinical practice than uncorrected Cr survival data.