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Fibrinogen Survival with [ 75 Se]Selenomethionine during l ‐Asparaginase Therapy
Author(s) -
Brodsky Isadore,
Kahn S. Benham,
Vash George,
Ross Evelyn M.,
Petkov Goldie
Publication year - 1971
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1971.tb07062.x
Subject(s) - fibrinogen , medicine , asparaginase , catabolism , anabolism , immunology , endocrinology , gastroenterology , leukemia , metabolism , lymphoblastic leukemia
S ummary . Fibrinogen anabolism and catabolism in four patients (acute lymphoblastic leukaemia; lymphosarcoma cell leukaemia; generalized lymphosarcoma; hypernephroma) were determined with [ 75 Se]selenomethionine during a period of hypofibrinogenaemia induced by l ‐asparaginase. The anabolic phase was normal but the fibrinogen survival decreased to 1.5–4.0 days (normal range, 7.8 ± 2.8 days). Heparin therapy did not affect either the fibrinogen levels or abnormal thrombin times. In two patients with widespread Hodgkin's disease in whom l ‐asparaginase therapy was started after the labelling of fibrinogen with [ 75 Se]selenomethionine, the fibrinogen survival was normal. The results suggest the production of an intrinsically abnormal fibrinogen with a decreased survival during l ‐asparaginase administration.