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Nervous Regulation of Factor‐VIII Levels in Man
Author(s) -
Mannucci P. M.,
Ruggeri Z. M.,
Gagnatelli Giovanna
Publication year - 1971
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1971.tb07028.x
Subject(s) - chemistry , medicine , endocrinology
S ummary . Neurological procedures such as pneumoencephalography (PE), electro‐shock (ES), electrocoagulation (EC) of the ventrolateral thalamic nucleus, cerebral arteriography and myelography have been studied as experimental models in which to investigate in man the effect on plasma factor‐VIII levels of stresses applied to the CNS. A marked elevation of factor VIII followed PE and ES; the factor‐VIII levels showed some fluctuations over the period of experimental observation. The other coagulation factors were unchanged. A three‐fold increase of factor VIII was also observed after PE in a subject with mild haemophilia A. EC was followed by a significant rise of factor VIII, which was however much lower than after PE and ES. No significant change was produced by the other procedures. A number of experiments have been carried out to investigate the possibility that the observed increase might be artefactual. No evidence has been obtained that the rise measured with the bioassay results from some sort of activation or potentiation of the factor‐VIII molecule, rather than from a true molecular increase. It is suggested that the phenomenon is related to the stimulation by PE and ES of discrete neuronal structures regulating the plasma levels of factor VIII through a mechanism at present unknown.