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Four Cases of Acquired von Willebrand's Syndrome
Author(s) -
Ingram G. I. C.,
Kingston P. J.,
Leslie J.,
Bowie E. J. W.
Publication year - 1971
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1971.tb03429.x
Subject(s) - haemophilia , medicine , von willebrand factor , von willebrand disease , disease , coagulopathy , systemic lupus erythematosus , immunology , gastroenterology , pediatrics , platelet
S ummary . Four cases are reported in which a bleeding disorder associated with a long bleeding time and a low factor‐VIII level, like von Willebrand's disease, appears to have developed in adult life. In each there were abnormalities of plasma proteins, similar to but in some instances more extreme than patterns found in haemophilia and ‘classical’ von Willebrand's disease. One patient's bleeding tendency developed in association with a generalized illness, probably systemic lupus erythematosus, and improved rapidly on steroid treatment. The other three patients, with no symptoms of underlying disease, were not treated with steroids. Two patients, infused with plasma, showed rather more than the predicted rise in factor VIII.