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Loss of the Y Chromosome in Myelodysplasia: A Report of Three Cases Studied with Quinacrine Fluorescence
Author(s) -
Rowley Janet D.
Publication year - 1971
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1971.tb02734.x
Subject(s) - karyotype , splenectomy , prednisone , cytogenetics , y chromosome , medicine , chromosome , long arm , biology , gynecology , genetics , spleen , gene
S ummary . Three males with a variable proportion of 45, X cells in their bone marrow were observed among 100 males examined. All three were found in a group of 57 males who had some haematologic disorder. No Y‐minus males were observed in a group of 37 males who had other, non‐haematologic disorders, or among six volunteers. Quinacrine fluorescence was used to precisely identify the missing small acrocentric chromosome as the Y. One of the three males with a Y minus cell line was 55 yr; the other two were over 60 yr of age. All three males had thrombocytopenia which had been treated with prednisone and two had undergone splenectomy. One of the cases has shown a disappearance of his aneuploid cells over a 14 mth period. One other case has shown an increase in the proportion of 45, X cells during a 2 yr interval.