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Intracellular Hydrogen Transport Systems in Acute Leukaemia
Author(s) -
Stuart J.,
Simpson J. S.,
Mann J. R.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb07019.x
Subject(s) - lymphoblast , lactate dehydrogenase , enzyme , intracellular , succinate dehydrogenase , dehydrogenase , mitochondrion , biochemistry , biology , chemistry , cell culture , genetics
S ummary . A cytochemical study of intra‐ and extra‐mitochondrial dehydrogenase enzymes in human leukaemic lymphoblasts has shown an increase in activity, relative to the small lymphocyte, of those enzymes which are extramitochondrial in location. In contrast, there was no significant increase in the activity of intramitochondrial respiratory dehydrogenases or of an α‐glycerolphosphate dehydrogenase which is thought to regulate hydrogen transport across the mitochondrial membrane. The findings are in keeping with a hypothesis that leukaemic blast cells show diminished hydrogen transport to the intramitochondrial respiratory pathway. A compensatory increase in lactate dehydrogenase activity in these cells may signify a degree of metabolic dependence on this enzyme, and its selective inhibition by oxamate analogues may therefore result in a cytotoxic effect.