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Irreversibly Sickled Cells and Splenomegaly in Sickle‐Cell Anaemia
Author(s) -
Serjeant Graham R.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01647.x
Subject(s) - medicine , spleen , immunology
S ummary Low levels of irreversibly sickled cells occur in patients with sickle‐cell anaemia and splenomegaly. The Hb F level appears to influence both the level of ISCs and the persistence of splenomegaly. It is suggested that low levels of ISCs allow splenomegaly to persist and hence are the cause and not primarily the result of persistent splenomegaly.