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Milder Variant of Sickle‐Cell Disease in Arabs in Kuwait associated with Unusually High Level of Foetal Haemoglobin
Author(s) -
Ali Syed Amir
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01645.x
Subject(s) - brother , disease , medicine , pediatrics , family studies , sickle cell anemia , biology , genetics , sociology , anthropology
S ummary Two families with a new form of relatively benign sickle‐cell disease in Arabs are described here. In the first family, born to AS parents, four children, all above the age of 10 years, had mild manifestation of the sickle‐cell disease. The haemoglobin pattern of these four children is that of SF with complete absence of HbA on the Hb electrophoresis. There was no evidence of thalassaemia minor in the parents. In the second family, two brothers with sickle‐cell disease showed on electrophoresis true SF pattern. Both were above the age of 12 and never needed blood transfusion before, except on recent admission of the younger brother to hospital. The elder brother was not anaemic and was free of symptoms though he has homozygous sickle‐cell disease. Haematological details of a few similar individual cases where family studies were not possible are also reported.