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Erythrocyte Glutathione‐Peroxidase Deficiency
Author(s) -
Necheles Thomas F.,
Steinberg Martin H.,
Cameron Dorothy
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01644.x
Subject(s) - haemolysis , jaundice , glutathione peroxidase , enzyme , peroxidase , enzyme deficiency , glutathione , medicine , chemistry , biochemistry , immunology
S ummary Glutathione peroxidase deficiency is the most recently described erythrocyte enzyme abnormality. This enzyme occupies a critical position in the pathways leading to the decomposition of peroxides in the erythrocyte. On the basis of our studies of patients with GSH‐P deficiency, it appears that a spectrum of disease quite similar to that found in G‐6‐PD deficiency is present; this includes compensated haemolytic disease, drug‐induced haemolysis and neonatal jaundice.