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Red Cell Acetylcholinesterase Activity in Autoimmune Haemolytic Anaemias
Author(s) -
Sirchia G.,
Ferrone S.,
Mercuriali F.,
Zanella A.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01637.x
Subject(s) - red cell , acetylcholinesterase , autoantibody , autoimmune hemolytic anemia , immunology , enzyme , medicine , chemistry , biochemistry , antibody
S ummary . Red cell acetylcholinesterase activity was determined in 59 patients suffering from autoimmune haemolytic anaemia, classified according to the types of erythrocyte‐coating globulins. The enzyme activity was found significantly subnormal in the γG and the γG+C' types of AIHA, while it was not significantly lower than normal in the group of patients where complement (C') alone coated the red cells. These results suggest that different types of autoantibodies are able to cause different biochemical alterations of the red cells.