Two Haemoglobins Q, α74 (EF3) and α75 (EF4) Aspartic Acid→Histidine | Zendy

Lorkin P. A. | Zendy; Charlesworth D. | Zendy; Lehmann H. | Zendy; Rahbar S. | Zendy; Tuchinda S. | Zendy; Eng Lie Injo Luan | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Two Haemoglobins Q, α74 (EF3) and α75 (EF4) Aspartic Acid→Histidine

Author(s) -

Lorkin P. A.,

Charlesworth D.,

Lehmann H.,

Rahbar S.,

Tuchinda S.,

Eng Lie Injo Luan

Publication year - 1970

Publication title -

british journal of haematology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.907

H-Index - 186

eISSN - 1365-2141

pISSN - 0007-1048

DOI - 10.1111/j.1365-2141.1970.tb01607.x

Subject(s) - histidine , aspartic acid , amino acid substitution , mutation , lysine , genetics , chemistry , microbiology and biotechnology , biology , gene , amino acid

S ummary Six samples of Haemoglobin Q were examined, three from Iran, two from Thailand, and one from California (Chinese). They all yielded identical fingerprints. The substitution was found to be α74 or 75 aspartic acid→histidine in five of the samples. In one from Thailand ‘sequencing’ established the mutation to be at position α74 (EF3), and in one from Iran it was at position α75 (EF4). It is suggested that the gene for the α‐chain of the South East Asian haemoglobin is linked with one for α thalassaemia.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research