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Leucocyte Alloantigens in the Kidney I. SEROLOGICAL IDENTIFICATION
Author(s) -
Jones J. Verrier,
Moore Barbara
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01604.x
Subject(s) - serology , antigen , kidney , immunology , cytotoxicity , pathology , biology , microbiology and biotechnology , medicine , antibody , in vitro , genetics
S ummary Glomeruli have been prepared from 12 sets of human cadaver kidneys. They have been used to absorb polyspecific leucocyte alloantisera, and leucocyte alloantigens have been demonstrated in 11 out of 12 sets of glomeruli. In three cases, alloantigens detected on the patient's leucocytes were shown to be present in the glomeruli. In one case, the glomeruli contained, in addition, an antigen not detected on the leucocytes by cytotoxicity. In one case, using a monospecific alloantiserum, the antigen T12 was detected on leucocytes and glomeruli.