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Exchange between Parenteral and Tissue Folate in Man
Author(s) -
Chanarin I.,
Perry Janet
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01594.x
Subject(s) - folic acid , chemistry , biochemistry , medicine , endocrinology
Reduced folate compounds (dihydro‐ and tetrahydro pteroylglutamic acid) given intravenously in man exchange rapidly and completely with tissue 5‐methyltetrahydrofolate which accumulates in plasma. Following an intravenous dose and before exchanging with tissue methylfolate the reduced compounds are altered to a heat stable form of folate, probably pteroylglutamic acid, in the plasma of control subjects. This does not take place in the plasma of patients with untreated pernicious anaemia where the injected folate remains in the reduced state until exchanged with tissue folate.