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Continuous Intravenous Infusion of Factor VIII in Classic Haemophilia
Author(s) -
McMillan Campbell W.,
Webster William P.,
Roberts Harold R.,
Blythe William B.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01591.x
Subject(s) - continuous infusion , haemophilia , haemophilia a , medicine , anesthesia , chemistry , surgery
The effects of continous intravenous infusion of factor VIII were studied under varied conditions in five children with classic haemophilia. Factor‐VIII activity was stable at room temperature (73–76°F) up to 12 hr in cryoprecipitates from fresh plasma and up to 27 hr in glycine‐precipitated fractions (Fraction AA and Method 4, Hyland). Constant infusion (17 ml/hr) of different concentrations of these fractions produced levels of plasma factor‐VIII activity which were proportional to the dose‐rate and became relatively steady after 12‐18 hr. In separate studies of two of the subjects, dental extraction and laminectomies were uneventfully supported by an initial dose of factor VIII followed by continuous infusions. It is suggested that continuous intravenous infusion of factor VIII is useful for studying the regulation of factor‐VIII levels in plasma and for maintaining steady plasma factor‐VIII activity during replacement therapy.