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The Coagulation Mechanism in Acute Bacterial Infection
Author(s) -
Goldenfarb Paul B.,
Zucker Stanley,
Corrigan James J.,
Cathey Mary H.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01589.x
Subject(s) - fibrinogen , coagulation , disseminated intravascular coagulation , fibrin , subclinical infection , medicine , platelet , immunology , gastroenterology
Successive coagulation studies were performed in 34 adult patients hospitalized for treatment of acute bacterial infection. Increased fibrinogen, factor‐VIII activity, and platelets were found in more than 50% of the patients studied. Classical disseminated intravascular coagulation occurred in three cases. Nine patients had elevated fibrin split products in various combinations with transient hypofibrinogenaemia, thrombocytopenia, and reduced factor‐V activity. The appearance of elevated fibrin split products together with transient hypofibrinogenaemia, thrombocytopenia, and reduced factor‐V activity in some patients may reflect the presence of subclinical disseminated intravascular coagulation.