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Intestinal Absorption of Reduced Folate Compounds in Man
Author(s) -
Perry Janet,
Chanarin I.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01447.x
Subject(s) - oral administration , folic acid , chemistry , tritium , methylation , absorption (acoustics) , pharmacology , biochemistry , medicine , physics , nuclear physics , acoustics , gene
S ummary . Oral administration of folate compounds was followed by a rise in L. casei active factors in blood. This was due to reduction and methylation of the folate compounds in the small gut and this was demonstrated by the use of dihydropteroylglutamic acid labelled with tritium. Parenteral administration of tritium‐labelled folate analogues was followed by a rapid exchange with unlabelled L. casei active folate from tissues.