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An Example of Polyagglutinability Due to the Tn Antigen
Author(s) -
Gunson H. H.,
Stratton F.,
Mullard G. W.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01445.x
Subject(s) - typing , abo blood group system , antigen , immunology , microbiology and biotechnology , biology , chemistry , genetics
S ummary . A case of atypical polyagglutinability due to the Tn antigen is described. The patient, although apparently healthy, has leucopenia and thrombocytopenia. Her cells presented the usual difficulties of polyagglutinable cells due to the presence of anti‐Tn in typing reagents whether of human or animal origin. The practical advantages, particularly in ABO typing, of using papain to destroy the T and Tn receptors has been demonstrated. Anti‐Tn, like anti‐T, is a 19S and probably a γM globulin. It has been clearly shown that Tn cells differ from T‐activated polyagglutinable cells and Cad positive cells, but it has not been possible to convert normal cells to Tn cells. Certain aspects of both typical and atypical polyagglutinability have been discussed.