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Coagulation Factor IX in Normal and Haemophilia B Plasma
Author(s) -
Somer J. B.,
Castaldi P. A.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb01430.x
Subject(s) - factor ix , coagulation , haemophilia b , haemophilia , haemophilia a , human plasma , chemistry , medicine , factor x , immunology , biochemistry , chromatography , thrombin , surgery , platelet
S ummary . Coagulation factor IX has been isolated in a partially purified form from normal human plasma. Studies have been performed of the coagulant properties of this factor, of its activation by contact product and subsequent reaction with factor VIII. A similar chromatographic procedure with DE AE cellulose has been used to study the plasma of a patient with haemophilia B. A fraction has been isolated with similar physico‐chemical properties to normal factor IX but lacking coagulant activity.