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The Role of Platelets in Fibrinolysis
Author(s) -
Ekert Henry,
Friedlander Isabel,
Hardisty R. M.
Publication year - 1970
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1970.tb00779.x
Subject(s) - platelet , plasmin , fibrinolysis , chemistry , fibrin , lysis , incubation , thrombin , kinetics , platelet activation , biochemistry , medicine , endocrinology , immunology , enzyme , biology , physics , quantum mechanics
Inhibition of plasmin and activation of plasminogen by platelet‐poor plasma, intact, lysed and thrombin‐aggregated platelet‐rich plasma, and washed platelets was studied by means of fibrin‐agar plates. No significant activation of plasminogen by platelets could be demonstrated. Maximal inhibition of plasmin occurred after 2–3 hr incubation with either platelet‐rich or platelet‐poor plasma; in each case the kinetics of the reaction were suggestive of non‐competitive inhibition. Platelets showed both adsorbed and intrinsic anti‐plasmin activity, but the latter was equivalent to only about 1% of the total plasma activity.