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Ineffective Erythropoiesis with Morphologically Abnormal Erythroblasts and Unconjugated Hyperbilirubinaemia
Author(s) -
Verwilghen R.,
Verhaegen H.,
Waumans P.,
Beert J.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb05661.x
Subject(s) - ineffective erythropoiesis , erythropoiesis , abnormality , erythroblast , bone marrow , multinucleate , medicine , pathology , anemia , psychiatry
S ummary . Four cases of congenital dyserythropoietic anaemia in two families are described. The evidence for a dyserythropoietic state is discussed and the suggestion made that the hyperbilirubinaemia of the unconjugated type is mainly due to intramedullary bilirubin formation. Many abnormal multinucleated erythroblasts were found in the bone marrow. The evidence for a membrane defect and a possible haemoglobin abnormality have been presented.