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Erythropoiesis, Red‐Cell Creatine and Plasma Aldolase Activity in Anaemia in the Rabbit and Man
Author(s) -
Griffiths W. J.,
Lothian Elizabeth J.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb01396.x
Subject(s) - aldolase a , erythropoiesis , medicine , red cell , endocrinology , fructose bisphosphate aldolase , bone marrow , enzyme , biology , chemistry , biochemistry , anemia
S ummary . It has been shown that in the rabbit plasma aldolase was not increased by phlebotomy whereas in haemolytic anaemia produced by acctylphenylhydrazine there was a marked rise in plasma aldolase which was not, however, sustained throughout the period of falling haemoglobin. It is suggested that because of this dissociation of enzyme activity and haemoglobin the increased plasma aldolase activity in haeniolytic anaemia is not due to release of enzyme from the haemolysed red cells but that it is derived from immature precursor cells destroyed during transient ineffective erythropoiesis in the bone marrow. The data obtained from these animal experiments have been used to elucidate the cause of the raised plasma aldolase which is a feature of some types of human anaemia. In iron‐deficiency anaemia the plasma aldolase was not increased. In megaloblastic anacinia the plasma aldolase was increased in some but not in all patients. Evidence is adduced to support the hypothesis that the increase in plasma aldolase activity, when it is present, is due to release of enzyme from precursor cells destroyed in the marrow during ineffective erythropoiesis. The creatine content of the red cell has been used as an index of the mean age of the cells in the peripheral circulation. Increased red‐cell creatine in iron‐deficiency anaemia is considered to be the result of a shortened survival of the cells in this condition.