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Erythroid Cell Proliferation in Hypertransfused Rats
Author(s) -
Tarbutt R. G.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb01359.x
Subject(s) - cell growth , bone marrow , biology , immunology , microbiology and biotechnology , chemistry , medicine , cancer research , andrology , biochemistry
S ummary .55 Fe autoradiography of the circulating erythrocytes has been used to study the proliferation of erythroblasts in hypertransfused rats. The maturation time of the recognizable erythroid precursors labelled with 55 Fe 6 hours before hypertransfusion is not changed by the subsequent transfusion, and the number of labelled erythrocytes produced by these precursors is also normal. The results imply that the recognizable erythroid precursors present in the marrow at the time of hypertransfusion undergo the normal number of divisions in a normal maturation time, and therefore that the proliferation rate of these precursors is unchanged by hypertransfusion. The results have been discussed in terms of the role of erythro‐poietin in the control of erythroid cell proliferation.