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Sites of Red Cell Destruction in the Anaemia of Experimental Burns *
Author(s) -
Bhargava Manorama,
Agarwal K. N.,
Kumar Sharad
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb01357.x
Subject(s) - haemolysis , red cell , splenectomy , prednisolone , medicine , spleen , hemolysis , immunology , gastroenterology
S ummary . There are mainly two sites for red‐cell destruction following thermal burn injury in albino rats. Intravascular haemolysis as well as hepatic destruction of red cells account for the elimination of red cells from the circulation during anaemia observed as early as 24 hours following burns. The anaemia that occurs on the 6th day of burns is associated mainly with splenic sequestration of red cells. Prednisolone was found to be ineffective in inhibiting the splenic sequestration of red cells, but splenectomy almost completely prevents the progression of anaemia.