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The Inhibition of Activated Factor X with Di:isopropyl Fluorophosphate
Author(s) -
Leveson J. E.,
Esnouf M. P.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb01356.x
Subject(s) - isopropyl , diisopropyl fluorophosphate , moiety , esterase , chemistry , stereochemistry , microbiology and biotechnology , biochemistry , medicinal chemistry , biology , enzyme
S ummary . The esterase and coagulant activities of activated Factor X have been inhibited by radioactive di:isopropyl fluorophosphate. The amino acid sequence about the site of binding of the di:isopropyl moiety has been shown to be gly.asp.ser‐P‐gly.