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Effect of a Natural Phosphatidyl Serine Fraction on Blood Coagulation, Platelet Aggregation and Haemostasis
Author(s) -
Nishizawa E. E.,
Hovig T.,
Lotz F.,
Rowsell H. C.,
Mustard J. F.
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00427.x
Subject(s) - platelet , coagulation , thrombin , platelet aggregation , serine , chemistry , biochemistry , coagulation system , adenosine diphosphate , fraction (chemistry) , pharmacology , endocrinology , medicine , enzyme , chromatography
Summary: The intravenous infusion of a phosphatidyl serine fraction into pigs or dogs caused prolonged bleeding from transected vessels. This effect appeared to be due to inhibition of blood coagulation and of platelet aggregation induced both by collagen and by thrombin. This influence on the effect of thrombin and collagen on platelets may be attributed to suppression of the release of platelet constituents, including ADP, for the phosphatidyl serine fraction does not inhibit ADP‐induced aggregation.