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Renal Erythropoietic Factor—Some Properties and its Interaction with Histones
Author(s) -
Kuratowska Zofia,
Kopeć Maria
Publication year - 1969
Publication title -
british journal of haematology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.907
H-Index - 186
eISSN - 1365-2141
pISSN - 0007-1048
DOI - 10.1111/j.1365-2141.1969.tb00425.x
Subject(s) - erythropoietin , erythropoiesis , histone , neuraminidase , proteolytic enzymes , ineffective erythropoiesis , arginine , chemistry , enzyme , biology , biochemistry , endocrinology , medicine , anemia , amino acid , gene
Summary: The erythropoietic activity of renal erythropoietic factor (REF) is localized in the acidic nuclear protein fraction (NPF). The activity is destroyed by proteolytic enzymes and neuraminidase. Histones obtained from mammalian liver and chicken erythrocytes completely inhibit the erythropoietic activity of NPF. The most potent inhibitory effect was evoked by the arginine‐rich histone fraction. A tentative hypothesis concerning the role of the interaction between histones and erythropoietin in the regulation of erythropoiesis is proposed.